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New research reveals mutation responsible for disease resistance in Cassava


International research team aims to significantly reduce the threat of Cassava mosaic disease and improve cassava yields, an important crop in the tropics

Peer-Reviewed PublicationST. LOUIS, MO, July 13, 2022 — Groundbreaking research led by Rebecca Bart, PhD, associate member, and Nigel Taylor, PhD, associate member and Dorothy King distinguished investigator, Donald Danforth Plant Science Center, and their collaborators at ETH Zurich, University of California Los Angeles, and the National Crops Resources Research Institute (NaCRRI) in Uganda, has identified a genetic mutation that confers resistance to cassava mosaic disease (CMD). Their findings have significant implications for improving cassava yield and sustaining farmer income in the face of a widespread disease, and their discovery could also shed light on disease-resistance in other major crops. This seminal work, Mutations in DNA polymerase δ subunit 1 co-segregate with CMD2-type resistance to cassava mosaic geminiviruses, was recently published in the scientific journal Nature CommunicationsDOI 10.1038/s41467-022-31414-0.

Cassava, a starchy root crop rich in carbohydrates, is one of the most important staple foods in the world; it feeds nearly one billion people, mostly in the tropics. Cassava is considered a staple in many developing countries, especially among small holder farmers, due to its drought-tolerance and ability to grow in poor soils. However, farmers in Africa, India, and Southeast Asia – some of the largest cassava producing regions in the world – too often suffer huge yield losses due to CMD. CMD infected plants are stunted and do not fully develop the storage roots that are used for food.

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