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2022-10-23T00:47:00.0000000Z
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Insights into pathogen-host interaction offer a clue to protecting crops from blast

John Innes Centre

A mechanism used by a fungal pathogen to promote spread of the devastating cereal crop disease, blast, has been revealed in fine detail. 

The Banfield group at the John Innes Centre, in collaboration with the Iwate Biotechnology Research Centre in Japan and The Sainsbury Laboratory in Norwich describes how an effector protein (AVR-Pii) used by the blast fungus Maganaporthe oryzae binds with the rice host receptor protein Exo70.  

Using protein structure analysis, the study reveals a tight binding mechanism in which a significant proportion of the effector surface is involved in the interaction with the host target.   

In revealing the structure of AVR-Pii, the research group have also shown that this effector  belongs to a new protein family in the blast pathogen, termed “Zifs”, as they are based on a Zinc-finger motif. 

Read on: https://www.jic.ac.uk/news/insights-into-pathogen-host-interaction-offer-a-clue-to-protecting-crops-from-blast/

Rice
Blast
Maganaporthe_oryzae

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